Chgb-CreERT2 mouse line

Inducible Cre driver for neuroendocrine Chgb-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Chgb
Target system:
Endocrine system, neuroendocrine tissues
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:6122679

Scientific relevance & applications  

CHGB encodes chromogranin B, a secretory protein expressed in neuroendocrine cells and involved in hormone storage and secretion. It is widely used as a marker of neuroendocrine tissues. The Chgb-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Chgb-expressing neuroendocrine cells following tamoxifen administration. This model is suitable for studying endocrine signaling, hormone secretion, and neuroendocrine biology.

Chgb-CreERT2 mouse line

mouse line

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