Crygb-CreERT2 mouse line

Inducible Cre driver for ocular and Crygb-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Crygb
Target system:
Eye, lens and ocular tissues
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:6122649

Scientific relevance & applications  

CRYGB encodes gamma-crystallin B, a structural protein expressed in the lens of the eye and essential for maintaining lens transparency and optical properties. Crystallins are critical for lens development and function. The Crygb-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Crygb-expressing ocular cells following tamoxifen administration. This model is suitable for studying lens biology, eye development, and ocular diseases such as cataracts.

Crygb-CreERT2 mouse line

mouse line

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