Dagla-CreERT2 mouse line

Inducible Cre driver for neuronal and metabolic Dagla-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Dagla
Target system:
Nervous system, metabolism
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:6122675

Scientific relevance & applications  

DAGLA encodes diacylglycerol lipase alpha, an enzyme involved in endocannabinoid synthesis, particularly in the production of 2-arachidonoylglycerol (2-AG). It is expressed in neuronal tissues and plays a role in synaptic signaling and metabolic regulation. The Dagla-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Dagla-expressing cells following tamoxifen administration. This model is suitable for studying endocannabinoid signaling, neuronal communication, and metabolic pathways.

Dagla-CreERT2 mouse line

mouse line

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