Dbx1-CreERT2 mouse line

Inducible Cre driver for neuronal Dbx1-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Dbx1
Target system:
Nervous system
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:5659565

Scientific relevance & applications  

DBX1 is a homeobox transcription factor expressed in specific progenitor domains of the developing central nervous system, where it plays a critical role in neuronal specification and circuit formation. Dbx1-expressing progenitors give rise to defined neuronal populations involved in respiratory and locomotor networks. The Dbx1-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Dbx1-expressing neuronal populations following tamoxifen administration. This model is particularly suited for studying neural development, circuit formation, and functional neuroscience.

Dbx1-CreERT2 mouse line

mouse line

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