Gast-CreERT2 mouse line

Inducible Cre driver for gastric epithelial Gast-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Gast
Target system:
Gastrointestinal tract, stomach
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:5659573

Scientific relevance & applications  

GAST encodes gastrin, a hormone primarily expressed in G cells of the gastric epithelium, where it regulates gastric acid secretion and gastrointestinal function. Its expression is highly specific to the stomach and plays a key role in digestive physiology. The Gast-CreERT2 mouse line enables inducible, temporal control of genetic recombination in gastrin-expressing gastric epithelial cells following tamoxifen administration. This model is well suited for studying gastric biology, epithelial cell function, and gastrointestinal diseases.

Gast-CreERT2 mouse line

mouse line

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