Gnai1-CreERT2 mouse line

Inducible Cre driver for Gnai1-expressing cells across multiple tissues

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Gnai1
Target system:
Ubiquitous, signaling pathways
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:6122681

Scientific relevance & applications  

GNAI1 encodes a G protein subunit involved in intracellular signaling pathways regulating cell communication, proliferation, and metabolism. It is expressed across multiple tissues and plays a role in diverse physiological processes. The Gnai1-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Gnai1-expressing cells following tamoxifen administration. This model is suitable for studying G protein-coupled signaling and pathway regulation across different biological systems.

Gnai1-CreERT2 mouse line

mouse line

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