Hrg-CreERT2 mouse line

Inducible Cre driver for hepatic and circulating Hrg-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Hrg
Target system:
Liver, circulatory system
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:6122923

Scientific relevance & applications  

HRG encodes histidine-rich glycoprotein, a plasma protein produced mainly by the liver and involved in coagulation, immune regulation, and angiogenesis. It circulates in the bloodstream and participates in multiple systemic processes. The Hrg-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Hrg-expressing cells following tamoxifen administration. This model is suitable for studying liver function, vascular biology, and systemic regulatory pathways.

Hrg-CreERT2 mouse line

mouse line

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