Il7-CreERT2 mouse line

Inducible Cre driver for immune and lymphoid Il7-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Il7
Target system:
Immune system, lymphoid tissues
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:6122639

Scientific relevance & applications  

IL7 encodes interleukin-7, a cytokine essential for lymphocyte development, survival, and homeostasis. It is expressed in stromal cells of lymphoid organs and plays a critical role in T cell and B cell biology. The Il7-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Il7-expressing stromal and immune-supporting cells following tamoxifen administration. This model is particularly suited for studying immune system development, lymphoid tissue function, and immunological disorders.

Il7-CreERT2 mouse line

mouse line

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