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MBP encodes myelin basic protein, a major structural component of the myelin sheath produced by oligodendrocytes in the central nervous system. It is a well-established marker of myelinating glial cells and is essential for proper nerve conduction. The Mbp-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Mbp-expressing oligodendrocytes following tamoxifen administration. This model is widely used for studying myelination, demyelinating diseases, and glial cell biology.
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