Mbp-CreERT2 mouse line

Inducible Cre driver for oligodendrocyte Mbp-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Mbp
Target system:
Nervous system, glial cells
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:6122918

Scientific relevance & applications  

MBP encodes myelin basic protein, a major structural component of the myelin sheath produced by oligodendrocytes in the central nervous system. It is a well-established marker of myelinating glial cells and is essential for proper nerve conduction. The Mbp-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Mbp-expressing oligodendrocytes following tamoxifen administration. This model is widely used for studying myelination, demyelinating diseases, and glial cell biology.

Mbp-CreERT2 mouse line

mouse line

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