Myh2-CreERT2 mouse line

Inducible Cre driver for fast-twitch skeletal muscle Myh2-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Myh2
Target system:
Muscle, skeletal muscle
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:6122677

Scientific relevance & applications  

MYH2 encodes myosin heavy chain 2, a major contractile protein expressed in fast-twitch skeletal muscle fibers. It plays a key role in muscle contraction and fiber-type specification. The Myh2-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Myh2-expressing muscle fibers following tamoxifen administration. This model is well suited for studying skeletal muscle physiology, fiber-type dynamics, and neuromuscular diseases.

Myh2-CreERT2 mouse line

mouse line

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