Myo1a-CreERT2 mouse line

Inducible Cre driver for intestinal epithelial Myo1a-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Myo1a
Target system:
Gastrointestinal tract, intestinal epithelium
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:5659616

Scientific relevance & applications  

MYO1A encodes a class I myosin predominantly expressed in the brush border of intestinal epithelial cells, where it plays a key role in maintaining microvillar structure and epithelial function. Its expression is highly specific to enterocytes of the small intestine. The Myo1a-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Myo1a-expressing intestinal epithelial cells following tamoxifen administration. This model is particularly suited for studying intestinal biology, epithelial function, and gut homeostasis.

Myo1a-CreERT2 mouse line

mouse line

Get in touch about

Let us know how we can help
Scientific excellence

From model design to experimental results
Featured in 600+ scientific articles

Collaborative approach

Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions

Robust validation data on catalog models

Generated with biopharma partners and in-house

Innovative technologies

and guaranteed freedom to operate

Easy access to models

Models with certified health status from professional breeders in US and Europe