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NALCN encodes a sodium leak channel involved in regulating neuronal excitability and resting membrane potential. It is broadly expressed in the central nervous system and plays a role in neuronal activity and rhythmic behaviors. The Nalcn-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Nalcn-expressing neuronal populations following tamoxifen administration. This model is suitable for studying neuronal signaling, excitability, and neurological disorders.
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