Nalcn-CreERT2 mouse line

Inducible Cre driver for neuronal Nalcn-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Nalcn
Target system:
Nervous system
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:6122671

Scientific relevance & applications  

NALCN encodes a sodium leak channel involved in regulating neuronal excitability and resting membrane potential. It is broadly expressed in the central nervous system and plays a role in neuronal activity and rhythmic behaviors. The Nalcn-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Nalcn-expressing neuronal populations following tamoxifen administration. This model is suitable for studying neuronal signaling, excitability, and neurological disorders.

Nalcn-CreERT2 mouse line

mouse line

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