Nkx2-6-CreERT2 mouse line

Inducible Cre driver for cardiac and developmental Nkx2-6-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Nkx2-6
Target system:
Heart, development
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:6122919

Scientific relevance & applications  

NKX2-6 is a homeobox transcription factor involved in cardiac development and early embryonic patterning. It is expressed in developing heart tissues and plays a role in cardiogenesis and organ formation. The Nkx2-6-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Nkx2-6-expressing cells following tamoxifen administration. This model is suitable for studying heart development, congenital defects, and developmental biology.

Nkx2-6-CreERT2 mouse line

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