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NR5A1 (also known as SF-1) is a nuclear receptor critical for the development and function of steroidogenic tissues, including adrenal glands and gonads. It regulates genes involved in steroid hormone biosynthesis and reproductive development. The Nr5a1-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Nr5a1-expressing cells following tamoxifen administration. This model is widely used for studying endocrine development, steroidogenesis, and reproductive biology.
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