Pde1b-CreERT2 mouse line

Inducible Cre driver for neuronal Pde1b-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Pde1b
Target system:
Nervous system
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:6122680

Scientific relevance & applications  

PDE1B encodes a phosphodiesterase involved in cyclic nucleotide signaling and is highly expressed in specific neuronal populations of the brain, including regions involved in motor control and reward pathways. It plays a role in regulating intracellular signaling cascades. The Pde1b-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Pde1b-expressing neuronal cells following tamoxifen administration. This model is suitable for studying neuronal signaling, behavior, and neurological disorders.

Pde1b-CreERT2 mouse line

mouse line

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