Sfrp1-CreERT2 mouse line

Inducible Cre driver for Sfrp1-expressing cells involved in Wnt signaling regulation

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Sfrp1
Target system:
Development, signaling pathways
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:5659639

Scientific relevance & applications  

SFRP1 encodes a secreted modulator of Wnt signaling that regulates cell proliferation, differentiation, and tissue patterning. Its expression is observed in multiple tissues, particularly during development and in epithelial and stromal compartments. The Sfrp1-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Sfrp1-expressing cells following tamoxifen administration. This model is suitable for studying Wnt signaling, tissue development, and disease processes involving dysregulated signaling pathways.

Sfrp1-CreERT2 mouse line

mouse line

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