Spp2-CreERT2 mouse line

Inducible Cre driver for hepatic and metabolic Spp2-expressing cells

Availability & Delivery:

• Cryo-recovery using in-house SOPF facilities • Worldwide delivery by professional breeders

Specifications

Expression driver gene:
Spp2
Target system:
Liver, metabolism
Genetic background:
C57BL/6N
Cre type:
Inducible CreERT2
Reporter:
EGFP
Induction method:
Tamoxifen administration
MGI ID:
MGI:5659662

Scientific relevance & applications  

SPP2 encodes secreted phosphoprotein 2, a circulating protein primarily expressed in the liver and associated with metabolic processes and extracellular matrix interactions. Its expression is linked to systemic metabolic regulation and liver function. The Spp2-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Spp2-expressing hepatic cells following tamoxifen administration. This model is suitable for studying liver biology, metabolic regulation, and systemic signaling pathways.

Spp2-CreERT2 mouse line

mouse line

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