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TEX101 encodes a glycoprotein specifically expressed in male germ cells, where it is essential for sperm development and fertility. Its expression is highly restricted to testicular germ cells. The Tex101-CreERT2 mouse line enables inducible, temporal control of genetic recombination in Tex101-expressing germ cells following tamoxifen administration. This model is particularly suited for studying spermatogenesis, fertility, and reproductive biology.
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