Top pharma companies use genOway’s humanized CD3 mouse models to assess the efficacy of their TCEs
Efficacy testing of TCE in monotherapy
AstraZeneca tested AZD5863, a TCE targeting CD3 and Claudin 18.2, using our genO-panhCD3 mouse and observed tumor growth inhibition in mice implanted with CLDN18.2-expressing MC38 cells:
Adapted from Gaspar et al. 2025, J Immunother Cancer
Efficacy testing of TCE in combination therapy
Using the genO-hCD3ε mouse model, Pfizer showed that their new TCE, PF-07260437, induced significant tumor growth inhibition and CD8+ T-cell infiltration in the tumor. These effects were even stronger when used in combination therapy with a mouse anti-PD1, showing that this model is a useful tool for assessing different treatment regimens.
Adapted from Abayasiriwardana et al., 2025, Mol Cancer Ther
Discover a wide range of humanized mouse models designed for translatable TCE assessment
Our humanized CD3 mice have been intercrossed with a immune checkpoint (ICP) models to achieve higher predictability:
▶ Efficacy of bispecific or trispecific antibodies targeting hCD3 and/or hCD28, or of combination therapies:
- genO-panhCD3/hCD28
- genO-panhCD3/hPD-1
- genO-panhCD3/hPD-1/hPD-L1
- genO-panhCD3/hCD137 (4-1BB)
▶ Efficacy of Fc-mediated T-cell engagers:
- genO-panhCD3/hFcγR
▶ Efficacy of therapeutics with increased tolerance to human IgG1:
- genO-panhCD3/hIgG1
▶ PK assessment of compounds with extended half-life:
- genO-panhCD3/hSA/hFcRn
Explore our catalog of humanized cell lines that can be used in combination with our mouse models
As part of our catalog, we have a range of different tumor cell lines that can be used for performing efficacy assays in syngeneic models. Each cell line is extensively validated based on expression of the target protein and reporter cassette, as well as in tumor growth studies.
Find out which cell lines are compatible with each of our mouse models and click on cell lines to see more details:
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