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genO‑panhCD3
Humanized mice (target-specific)

Preclinical genO‑panhCD3 mouse model

genO‑panhCD3 immunocompetent mice enable the efficacy assessment of T-cell engagers, to study cancer cell recognition, immunosuppressant therapies, etc.

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Applications of the genO‑panhCD3 mouse model

Useful applications for researchers working in different biomedical fields, such as immuno-oncology and autoimmunity:

  • Assess the efficacy of T-cell engagers (TCE)
    • Perform tumor inhibition assays
    • Test TCE for inhibition of autoimmune diseases‍
  • Evaluate the safety of therapeutics, such as inducing cytokine release syndrome (CRS) via treatment with anti-CD3 antibodies

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Features

  • Physiological expression of human CD3
  • Lack of expression of the murine target gene
  • Fully functional, and with unchanged homeostasis, mouse immune system
  • Functional CD3/TCR interaction
  • Functional T/B-cell cooperation

Clients

AstraZeneca

Scientific articleScientific articlePosterPoster

Model Delivery & Logistics

  • Breeding facilities in the US and Europe through our trusted partners:
  • Quick, compliant, and reliable door-to-door delivery worldwide
  • Models with certified SOPF health status from AAALAC-accredited and PHS-assured professional breeders in the US and Europe

Validation data

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genO‑panhCD3

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Preclinical genO‑panhCD3 mouse model

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Scientific excellence

From model design to experimental results
Featured in 600+ scientific articles

Collaborative approach

Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions

Robust validation data on catalog models

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Innovative technologies

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Easy access to models

Models with certified health status from professional breeders in US and Europe