Design of the CT26-hPD‑L1 cell line

The CT26.WT cell line was derived and subcloned from Balb/c murine colon carcinoma and forms tumors at high frequency when inoculated subcutaneously. We generated a CT26‑hPD‑L1 clonal cell line expressing human PD‑L1.

Applications in immuno-oncology

As for our MC38-hPD-L1 cell line, the CT26-hPD-L1 cell line can be used for in vivo tumor growth assays in syngeneic models and in vitro mechanistic studies.

CT26-Pd-l1 Knockout tumor cell line:
Use our CT26-Pd-l1 Knockout clones for target validation and mechanistic studies.

CT26-hPD-L1 features

We generated a CT26-hPD-L1 clonal cell line expressing high levels of human PD-L1, and forming solid tumors in vivo.

  • They only express human PD-L1, as they are invalidated for murine Pd‑l1
  • hPD-L1 is entirely humanized
  • Strong and sustained expression of human PD-L1

Validation

Related ressources et publications

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