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Applications of the genO‑panhCD3/hCD28 mouse model
Useful applications for researchers working on different biomedical fields, such as immuno-oncology, and autoimmunity:
- Assess the efficacy of CD3 and/or CD28-targeting therapeutics such as:
- Immune checkpoint inhibitors
- T-cell engagers targeting CD3
- Test TCEs for the inhibition of autoimmune diseases
- Perform tumor growth inhibition assays in the context of monotherapy or combotherapy
- Investigate the mode of action (MoA) of various compounds and understand their therapeutic potential
- Evaluate the safety and toxicity of compounds
Features
- Physiological regulation and expression pattern of CD3 and human CD28
- Conserved interaction with CD3γ, CD3δ and CD3ζ subunits
- Fully functional mouse immune system
- Lack of expression of the murine target genes
Clients
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