Assess T cell-targeting agents in a mouse model which expresses both human FcγR and a humanized target

Discover our catalog of humanized FcγR mice

Our catalog of humanized FcγR mice:

• Was validated for efficacy assessment of therapeutics with biopharma partners
• Features functional humanized FcγR and human-like pattern of expression  

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Access validation data on base models:

• genO-hFcγR mouse model
• genO-panhCD3 mouse model
• genO-hPD-1 mouse model
• genO-hCCR8/hCCL1 mouse model

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What sets our humanized FcγR models apart?

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Our models present unique features:

• Fully functional humanized receptors (FcγRI, FcγRIIA, FcγRIIB, FcγRIIIA, FcγRIIIB) assessed in various immune cells including NK cells, T cells, and basophils.
• Human-like expression pattern of hFcγR that mirrors human FcγR diversity and distribution.
• No expression of murine FcγR
• Extensive dataset package generated with biopharma partners:
  • Efficacy assessment of lead marketed ADCC-inducing antibodies (Rituximab & Obinutuzumab)
  • Possibility to rank Fc-engineered antibodies
  • Fc-dependent B-cell depletion induced by Fc-engineered anti-CD20 antibodies

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The impact of our humanized FcγR models on our partners' research

Here is a non exhaustive list of scientific articles that were published using our humanized FcγR mouse model:

•  Analysis of Fc-dependent effector functions of anti-malaria circumsporozoite protein antibodies, Stefanutti et al., Microbiol Spectr, 2025

• Novel FcγR humanized mouse models enabling efficacy and PK/PD of therapeutic antibodies, Sônego et al., poster presented at AACR 2024

• ‍A Cross-Species Map and Humanized Mouse Model of Fcγ Receptors and FcRn, Van Damme et al., poster presented at EMDS 2023