Applications of the hPD‑1 mouse model

Useful applications for researchers working on different biomedical fields, such as  immuno-oncology, immuno-inflammation and autoimmunity:

  • Assess the efficacy of PD-1-targeting compounds
    • Perform tumor growth inhibition assays in the context of monotherapies or combotherapies
    • Evaluate PD-1 agonists for the treatment of autoimmune and inflammatory conditions
  • Gain insights into the mechanism of action (MOA) of diverse constructs and their potential therapeutic benefits

Features

  • Physiological regulation and expression of a humanized PD-1
  • Lack of expression of the murine target gene
  • Fully functional mouse immune system
  • Available on different genetic backgrounds C57BL/6 & BALB/c

Related resources and publications

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Validation data

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hPD-1

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The hPD-1/hCTLA-4 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint PD-1 and/or CTLA-4 in fully immunocompetent mice.

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The hPD-1/hGITR/hGITRL mouse model enables in vivo efficacy assessment and profiling of antibodies targeting human immune checkpoint PD-1, GITR and/or GITRL in fully immunocompetent mice.

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The hPD-1/hLAG3 mouse model enables in vivo efficacy assessment and profiling of antibodies targeting human immune checkpoint PD-1 and/or LAG3 in fully immunocompetent mice.

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The hPD-1/hPD-L1 mouse model enables in vivo efficacy assessment and profiling of molecules targeting the human PD-1/PD-L1 axis in fully immunocompetent mice.

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hPD-1/hTIM3

The hPD-1/hTIM3 mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint PD-1 and/or TIM3 in fully immunocompetent mice.

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The hPD-1/hVISTA mouse enables the in vivo efficacy assessment and profiling of immuno-oncology agents targeting the human immune checkpoint PD-1 and/or VISTA in fully immunocompetent mice.

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Preclinical humanized PD-1 mouse model

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