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genOway’s highlights at SITC 2025

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Our poster presentations

Below are the three posters presented by our team at the conference on Friday, 7 November and Saturday, 8 November, 2025:

Poster #443

‘Efficacy and safety assessment of CCR8-targeting agents in preclinical humanized models’ :

◆ Humanization of both CCR8 and CCL1 is required for a functional axis and does not alter immune cell distribution in genO-hCCR8/hCCL1 compared to WT mice

◆ CCR8-targeting therapies can be assessed in genO-hCCR8/hCCL1 model

◆ Human-like expression pattern of CCR8 in genO-BRGSF-HIS naïve Tregs makes it a more suitable model for safety and PD assessment

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Poster #835

'γδ T cells are functional and recruited into the TME in genO-BRGSF-HIS mice’

◆ γδ T cells develop in genO-BRGSF-HIS mice and can be expanded ex vivo and in vivo using Vγ9 expanders

◆ γδ T cells are recruited into the TME of tumor-bearing genO-BRGSF-HIS mice

◆ genO-BRGSF-HIS model brings a new perspective to evaluate therapies designed to expand and activate γδ T cells

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Poster #812‍‍

‘NK cell recruitment into A549 TME in genO-BRGSF-HIS mice’

◆ genO-BRGSF-HIS mouse is permissive to cell line xenograft engraftment

◆ TME composition and cell polarization evolve with tumor burden and depend on tumor type in genO-BRGSF-HIS mouse

◆ genO-BRGSF-HIS mouse model is a valuable tool to investigate mechanism of action of immunotherapies