Target

Gene symbol :  
Adam17
NCBI gene ID :  
11491
Gene full name :  
ADAM metallopeptidase domain 17
Synonym :  
TACE, CD156b

Protein function

Protein name :  
ADAM17
Cleaves membrane-bound cytokines and receptors; regulates inflammation and development.

Expected phenotype

Developmental defects, immune dysfunction

Human disease relevance

Target in inflammatory diseases and cancer

Model applications

TNF signaling, shedding enzymes, inflammation

Keywords:

Sheddase, Metalloprotease, Cytokines

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Adam17

conditional Knockout mouse

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