Target

Gene symbol :  
Alox12e
NCBI gene ID :  
11685
Gene full name :  
Arachidonate 12-lipoxygenase, epidermal type
Synonym :  
12e-lipoxygenase

Protein function

Protein name :  
ALOX12E
Produces 12-hydroxyeicosatetraenoic acid (12-HETE) involved in skin barrier function.

Expected phenotype

Abnormal skin barrier, lipid signaling changes

Human disease relevance

Implicated in ichthyosis and skin inflammation

Model applications

Skin biology, lipid metabolism

Keywords:

Lipoxygenase, Eicosanoids, Epidermis

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • WoldWide delivery by professional breeders

Alox12e

conditional Knockout mouse

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