Brpf1 conditional Knockout mouse

Target

Gene symbol :

Brpf1

NCBI gene ID :

78783

Gene full name :

Bromodomain and PHD finger containing 1 (Peregrin)

Synonym :

4833438B11Rik, 4930540D11Rik, Br140

Protein function

Protein name :

Bromodomain & PHD finger-containing protein 1

Chromatin reader and coactivator; part of MOZ/MORF HAT complexes; regulates H3 acetylation and gene expression

Expected phenotype

Knockouts lethal ~E9.5; brain and craniofacial defects

Human disease relevance

Mutations cause neurodevelopmental syndromes and cancers

Model applications

Used in chromatin regulation and developmental biology models

Keywords:

Chromatin remodeling, Epigenetics, HAT complex, Neurodevelopment

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Brpf1

conditional Knockout mouse

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