Cyp7a1 conditional Knockout mouse

Target

Gene symbol :

Cyp7a1

NCBI gene ID :

13122

Gene full name :

Cytochrome P450 family 7 subfamily A member 1

Synonym :

Cholesterol 7α-hydroxylase, Cyp7

Protein function

Protein name :

CYP7A1

Catalyzes first step in bile acid synthesis from cholesterol in the liver.

Expected phenotype

Elevated serum cholesterol, altered bile acid pool

Human disease relevance

Target in hypercholesterolemia and bile acid disorders

Model applications

Cholesterol metabolism, liver research

Keywords:

CYP450, Bile acids, Lipid metabolism

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Cyp7a1

conditional Knockout mouse

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