Target

Gene symbol :  
Cyp7a1
NCBI gene ID :  
13122
Gene full name :  
Cytochrome P450 family 7 subfamily A member 1
Synonym :  
Cholesterol 7α-hydroxylase, Cyp7

Protein function

Protein name :  
CYP7A1
Catalyzes first step in bile acid synthesis from cholesterol in the liver.

Expected phenotype

Elevated serum cholesterol, altered bile acid pool

Human disease relevance

Target in hypercholesterolemia and bile acid disorders

Model applications

Cholesterol metabolism, liver research

Keywords:

CYP450, Bile acids, Lipid metabolism

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Cyp7a1

conditional Knockout mouse

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