Def6 conditional Knockout mouse

Target

Gene symbol :

Def6

NCBI gene ID :

23853

Gene full name :

Differentially expressed in FDCP 6

Synonym :

IBP, SWAP-70-related Rac GEF 3

Protein function

Protein name :

DEF6

Guanine nucleotide exchange factor; regulates T-cell activation and function

Expected phenotype

Immunodeficiency, autoimmunity

Human disease relevance

Mutations cause lupus-like phenotypes and immunodeficiency

Model applications

Autoimmunity and T-cell development models

Keywords:

GEF, Immune regulation, Autoimmunity

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Def6

conditional Knockout mouse

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