Dhcr24 conditional Knockout mouse

Target

Gene symbol :

Dhcr24

NCBI gene ID :

74754

Gene full name :

24-dehydrocholesterol reductase

Synonym :

Seladin1, KIAA0018

Protein function

Protein name :

Delta(24)-sterol reductase

Enzyme in cholesterol biosynthesis; also acts as antioxidant

Expected phenotype

Knockouts exhibit altered brain cholesterol and neurodegeneration

Human disease relevance

Implicated in Alzheimer’s disease and cancer

Model applications

Used in cholesterol metabolism and neurodegeneration research

Keywords:

Cholesterol biosynthesis, Alzheimer’s, Reductase, Neuroprotection

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Dhcr24

conditional Knockout mouse

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