Target

Gene symbol :  
Dhcr24
NCBI gene ID :  
74754
Gene full name :  
24-dehydrocholesterol reductase
Synonym :  
Seladin1, KIAA0018

Protein function

Protein name :  
Delta(24)-sterol reductase
Enzyme in cholesterol biosynthesis; also acts as antioxidant

Expected phenotype

Knockouts exhibit altered brain cholesterol and neurodegeneration

Human disease relevance

Implicated in Alzheimer’s disease and cancer

Model applications

Used in cholesterol metabolism and neurodegeneration research

Keywords:

Cholesterol biosynthesis, Alzheimer’s, Reductase, Neuroprotection

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Dhcr24

conditional Knockout mouse

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