Target

Gene symbol :  
Gle1
NCBI gene ID :  
74412
Gene full name :  
GLE1, RNA export mediator
Synonym :  

Protein function

Protein name :  
Nucleoporin GLE1
Essential for mRNA export from the nucleus; also regulates translation and stress granules

Expected phenotype

Knockouts are embryonic lethal; essential for nuclear-cytoplasmic transport

Human disease relevance

Mutations cause LCCS1 and ALS-like syndromes

Model applications

Used in mRNA export and motor neuron disease research

Keywords:

mRNA export, Nucleocytoplasmic transport, ALS, Stress granules

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Gle1

conditional Knockout mouse

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