Gle1 conditional Knockout mouse

Target

Gene symbol :

Gle1

NCBI gene ID :

74412

Gene full name :

GLE1, RNA export mediator

Synonym :

—

Protein function

Protein name :

Nucleoporin GLE1

Essential for mRNA export from the nucleus; also regulates translation and stress granules

Expected phenotype

Knockouts are embryonic lethal; essential for nuclear-cytoplasmic transport

Human disease relevance

Mutations cause LCCS1 and ALS-like syndromes

Model applications

Used in mRNA export and motor neuron disease research

Keywords:

mRNA export, Nucleocytoplasmic transport, ALS, Stress granules

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Gle1

conditional Knockout mouse

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