Gpsm2 conditional Knockout mouse

Target

Gene symbol :

Gpsm2

NCBI gene ID :

76123

Gene full name :

G-protein signaling modulator 2

Synonym :

LGN, Gpsm2l

Protein function

Protein name :

G-protein-signaling modulator 2

Regulates mitotic spindle orientation and neurodevelopment

Expected phenotype

Knockouts show hearing loss and abnormal brain development

Human disease relevance

Mutations cause Chudley-McCullough syndrome (hearing + brain anomalies)

Model applications

Studied in neural polarity, spindle orientation, and hearing

Keywords:

Spindle orientation, G-protein signaling, Hearing, Neurodevelopment

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Gpsm2

conditional Knockout mouse

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Models with certified health status from professional breeders in US and Europe