Target

Gene symbol :  
Ikbkb
NCBI gene ID :  
16150
Gene full name :  
Inhibitor of kappaB kinase beta
Synonym :  
IKKβ, IKK2

Protein function

Protein name :  
IKKβ
Serine kinase that plays an essential role in the NF-κB signaling pathway, activated by multiple stimuli such as inflammatory cytokines.

Expected phenotype

Altered immune responses, increased neuronal excitability, and changes in disease severity in models of autoimmune encephalomyelitis.

Human disease relevance

Associated with combined immunodeficiency syndromes and various cancers.

Model applications

Studies on NF-κB signaling, inflammation, and immune responses.

Keywords:

NF-κB, Inflammation, Immunodeficiency

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Ikbkb

conditional Knockout mouse

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