Ikbkb conditional Knockout mouse

Target

Gene symbol :

Ikbkb

NCBI gene ID :

16150

Gene full name :

Inhibitor of kappaB kinase beta

Synonym :

IKKβ, IKK2

Protein function

Protein name :

IKKβ

Serine kinase that plays an essential role in the NF-κB signaling pathway, activated by multiple stimuli such as inflammatory cytokines.

Expected phenotype

Altered immune responses, increased neuronal excitability, and changes in disease severity in models of autoimmune encephalomyelitis.

Human disease relevance

Associated with combined immunodeficiency syndromes and various cancers.

Model applications

Studies on NF-κB signaling, inflammation, and immune responses.

Keywords:

NF-κB, Inflammation, Immunodeficiency

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Ikbkb

conditional Knockout mouse

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