Irak1 conditional Knockout mouse

Target

Gene symbol :

Irak1

NCBI gene ID :

16179

Gene full name :

Interleukin-1 receptor-associated kinase 1

Synonym :

IRAK-1

Protein function

Protein name :

IRAK1

Kinase involved in the Toll-like receptor and IL-1 receptor signaling pathways, leading to NF-κB activation.

Expected phenotype

Attenuated cytokine production and response to endotoxin.

Human disease relevance

Associated with systemic lupus erythematosus and other inflammatory diseases.

Model applications

Studies on innate immunity and inflammatory signaling.

Keywords:

TLR signaling, Inflammation, Autoimmunity

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Irak1

conditional Knockout mouse

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