Itch conditional Knockout mouse

Target

Gene symbol :

Itch

NCBI gene ID :

16396

Gene full name :

Itchy homolog (mouse)

Synonym :

Itchy E3 ubiquitin protein ligase

Protein function

Protein name :

ITCH

E3 ubiquitin ligase involved in the regulation of immune responses and protein degradation.

Expected phenotype

Autoimmune-like disease due to loss of function mutations.

Human disease relevance

Associated with syndromes involving immune dysregulation.

Model applications

Studies on protein ubiquitination and immune regulation.

Keywords:

Ubiquitin ligase, Immune regulation, Autoimmunity

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Itch

conditional Knockout mouse

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