Itgae conditional Knockout mouse

Target

Gene symbol :

Itgae

NCBI gene ID :

16407

Gene full name :

Integrin alpha E

Synonym :

CD103

Protein function

Protein name :

Integrin alpha-E

Mediates adhesion of intra-epithelial T-lymphocytes to epithelial cells via E-cadherin binding.

Expected phenotype

Altered immune cell localization and function.

Human disease relevance

Implicated in inflammatory bowel disease and graft-versus-host disease.

Model applications

Studies on mucosal immunity and T-cell localization.

Keywords:

Integrin, T-cell adhesion, Mucosal immunity

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Itgae

conditional Knockout mouse

Get in touch about

Let us know how we can help

Scientific excellence

From model design to experimental results
Featured in 600+ scientific articles

Collaborative approach

Collaboration with 17 Top Pharmas,
170+ Biotechs and 380+ Academic Institutions

Robust validation data on catalog models

Generated with biopharma partners and in-house

Innovative technologies

and guaranteed freedom to operate

Easy access to models

Models with certified health status from professional breeders in US and Europe