Itgae conditional Knockout mouse

Target

Gene symbol :

Itgae

NCBI gene ID :

16407

Gene full name :

Integrin alpha E

Synonym :

CD103

Protein function

Protein name :

Integrin alpha-E

Mediates adhesion of intra-epithelial T-lymphocytes to epithelial cells via E-cadherin binding.

Expected phenotype

Altered immune cell localization and function.

Human disease relevance

Implicated in inflammatory bowel disease and graft-versus-host disease.

Model applications

Studies on mucosal immunity and T-cell localization.

Keywords:

Integrin, T-cell adhesion, Mucosal immunity

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
WoldWide delivery by professional breeders

Itgae

conditional Knockout mouse

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