Kcnj11 conditional Knockout mouse

Target

Gene symbol :

Kcnj11

NCBI gene ID :

16514

Gene full name :

Potassium inwardly-rectifying channel, subfamily J, member 11

Synonym :

Kir6.2

Protein function

Protein name :

Kir6.2

Forms ATP-sensitive potassium channels regulating insulin secretion in pancreatic beta cells.

Expected phenotype

Impaired glucose-stimulated insulin secretion.

Human disease relevance

Mutations cause neonatal diabetes mellitus.

Model applications

Studies on insulin secretion and diabetes.

Keywords:

ATP-sensitive channel, Insulin regulation, Diabetes

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
WoldWide delivery by professional breeders

Kcnj11

conditional Knockout mouse

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