Knl1 conditional Knockout mouse

Target

Gene symbol :

Knl1

NCBI gene ID :

76464

Gene full name :

Kinetochore scaffold 1

Synonym :

CASC5, AF15q14

Protein function

Protein name :

Kinetochore scaffold protein KNL1

Essential for kinetochore assembly and chromosome segregation

Expected phenotype

Knockouts lead to mitotic errors and embryonic lethality

Human disease relevance

Mutations linked to microcephaly and mitotic syndromes

Model applications

Studied in mitosis, spindle checkpoint, and chromosome instability

Keywords:

Kinetochore, Mitosis, Chromosome segregation, Microcephaly

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Knl1

conditional Knockout mouse

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