Target

Gene symbol :  
Knl1
NCBI gene ID :  
76464
Gene full name :  
Kinetochore scaffold 1
Synonym :  
CASC5, AF15q14

Protein function

Protein name :  
Kinetochore scaffold protein KNL1
Essential for kinetochore assembly and chromosome segregation

Expected phenotype

Knockouts lead to mitotic errors and embryonic lethality

Human disease relevance

Mutations linked to microcephaly and mitotic syndromes

Model applications

Studied in mitosis, spindle checkpoint, and chromosome instability

Keywords:

Kinetochore, Mitosis, Chromosome segregation, Microcephaly

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Knl1

conditional Knockout mouse

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Models with certified health status from professional breeders in US and Europe