Lck conditional Knockout mouse

Target

Gene symbol :

Lck

NCBI gene ID :

16818

Gene full name :

Lymphocyte-specific protein tyrosine kinase

Synonym :

Lck proto-oncogene

Protein function

Protein name :

LCK

Src-family tyrosine kinase involved in T-cell receptor signaling.

Expected phenotype

Impaired T-cell development and activation

Human disease relevance

Targeted in T-cell malignancies and immunodeficiencies

Model applications

T-cell activation and immunotherapy models

Keywords:

TCR signaling, Src kinase, T-cell

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Lck

conditional Knockout mouse

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