Lonp1 conditional Knockout mouse

Target

Gene symbol :

Lonp1

NCBI gene ID :

74142

Gene full name :

Lon peptidase 1, mitochondrial

Synonym :

Prss15

Protein function

Protein name :

Lon protease homolog, mitochondrial

ATP-dependent protease involved in mitochondrial protein quality control

Expected phenotype

Knockouts cause embryonic lethality; heterozygotes show mitochondrial dysfunction

Human disease relevance

Mutations cause CODAS syndrome and mitochondrial disorders

Model applications

Used in mitochondrial proteostasis and metabolic disease studies

Keywords:

Mitochondria, Protease, Protein quality control, CODAS syndrome

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Lonp1

conditional Knockout mouse

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Models with certified health status from professional breeders in US and Europe