Lztr1 conditional Knockout mouse

Target

Gene symbol :

Lztr1

NCBI gene ID :

66863

Gene full name :

Leucine zipper–like transcriptional regulator 1

Synonym :

KLHL24, BTBD15

Protein function

Protein name :

LZTR1

Cullin-3–based E3 ligase adapter regulating Ras ubiquitination

Expected phenotype

RAS/MAPK pathway hyperactivation

Human disease relevance

Mutations cause Noonan syndrome–like disease and cancers

Model applications

Signal transduction & developmental models

Keywords:

E3 ligase, Ras/MAPK, Developmental

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Lztr1

conditional Knockout mouse

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