Map4k1 conditional Knockout mouse

Target

Gene symbol :

Map4k1

NCBI gene ID :

26411

Gene full name :

Mitogen-activated protein kinase kinase kinase kinase 1

Synonym :

HPK1

Protein function

Protein name :

MAP4K1

Activates JNK signaling downstream of TCR stimulation.

Expected phenotype

Impaired T-cell activation

Human disease relevance

Involved in immune regulation and cancer

Model applications

T-cell biology, MAPK pathway, cancer

Keywords:

MAPK, JNK, Immune signaling

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Map4k1

conditional Knockout mouse

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