Mpi conditional Knockout mouse

Target

Gene symbol :

Mpi

NCBI gene ID :

110119

Gene full name :

Mannose phosphate isomerase

Synonym :

MPIase

Protein function

Protein name :

Mannose-6-phosphate isomerase

Converts fructose-6-phosphate to mannose-6-phosphate in glycosylation pathways

Expected phenotype

Knockouts are embryonic lethal; hypomorphic models show glycosylation defects

Human disease relevance

Mutations cause congenital disorder of glycosylation type Ib

Model applications

Used in metabolic disease and glycosylation research

Keywords:

Glycosylation, Carbohydrate metabolism, CDG, Hexose interconversion

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Mpi

conditional Knockout mouse

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