Ndufs3 conditional Knockout mouse

Target

Gene symbol :

Ndufs3

NCBI gene ID :

68349

Gene full name :

NADH:ubiquinone oxidoreductase subunit S3

Synonym :

Ndufs3r, CI-30k

Protein function

Protein name :

NADH dehydrogenase [ubiquinone] iron-sulfur protein 3

Core subunit of mitochondrial Complex I; involved in electron transport and oxidative phosphorylation

Expected phenotype

Mitochondrial dysfunction; embryonic lethality in homozygous knockouts

Human disease relevance

Associated with Leigh syndrome and mitochondrial complex I deficiency

Model applications

Used to study mitochondrial diseases and oxidative phosphorylation defects

Keywords:

Mitochondria, Complex I, Leigh syndrome, Oxidative phosphorylation

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Ndufs3

conditional Knockout mouse

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