Target

Gene symbol :  
Notch1
NCBI gene ID :  
18128
Gene full name :  
Notch 1
Synonym :  
Notch homolog 1

Protein function

Protein name :  
Notch1
Transmembrane receptor involved in cell fate decisions.

Expected phenotype

Abnormal cell differentiation; increased tumorigenesis.

Human disease relevance

Implicated in T-cell acute lymphoblastic leukemia and other cancers.

Model applications

Research on cell differentiation and oncogenesis.

Keywords:

Notch signaling, Cell fate determination, Cancer

Availability & Delivery:

  • Cryo-recovery using in-house SOPF facilities
  • Worldwide delivery by professional breeders

Notch1

conditional Knockout mouse

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