Npc1 conditional Knockout mouse

Target

Gene symbol :

Npc1

NCBI gene ID :

18145

Gene full name :

NPC intracellular cholesterol transporter 1

Synonym :

Niemann-Pick disease, type C1

Protein function

Protein name :

NPC1

Mediates intracellular cholesterol trafficking; essential for lipid homeostasis.

Expected phenotype

Cholesterol accumulation; neurodegeneration.

Human disease relevance

Causes Niemann-Pick disease type C1.

Model applications

Models for lipid storage disorders and neurodegeneration.

Keywords:

Cholesterol transport, Lysosomal storage, Neurodegeneration

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Npc1

conditional Knockout mouse

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