Pnp conditional Knockout mouse

Target

Gene symbol :

Pnp

NCBI gene ID :

18950

Gene full name :

Purine nucleoside phosphorylase

Synonym :

Purine nucleoside phosphorylase

Protein function

Protein name :

PNP

Enzyme in purine salvage pathway; essential for T-cell survival.

Expected phenotype

Severe T-cell immunodeficiency

Human disease relevance

Causes purine nucleoside phosphorylase deficiency

Model applications

Immunodeficiency modeling, purine metabolism

Keywords:

Purine salvage, T-cell immunity, Enzyme deficiency

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Pnp

conditional Knockout mouse

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