Prmt5 conditional Knockout mouse

Target

Gene symbol :

Prmt5

NCBI gene ID :

27374

Gene full name :

Protein arginine methyltransferase 5

Synonym :

JBP1, HRMT2B

Protein function

Protein name :

PRMT5

Catalyzes symmetrical arginine methylation on histones and splicing factors

Expected phenotype

Embryonic lethality, germ cell defects

Human disease relevance

Overexpressed in various cancers; mutations impact development

Model applications

Epigenetics, cancer, germline studies

Keywords:

Methylation, Epigenetics, Cancer

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Prmt5

conditional Knockout mouse

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