Rpe65 conditional Knockout mouse

Target

Gene symbol :

Rpe65

NCBI gene ID :

19892

Gene full name :

Retinoid isomerohydrolase RPE65

Synonym :

RPE65, LRAT-associated protein

Protein function

Protein name :

RPE65

Essential enzyme in visual cycle converting all-trans-retinol to 11-cis-retinol

Expected phenotype

Visual cycle defects, photoreceptor degeneration

Human disease relevance

Mutations cause Leber congenital amaurosis and retinitis pigmentosa

Model applications

Visual cycle and gene therapy research

Keywords:

Visual cycle, Retina, Photoreceptor

Availability & Delivery:

Cryo-recovery using in-house SOPF facilities
Worldwide delivery by professional breeders

Rpe65

conditional Knockout mouse

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Models with certified health status from professional breeders in US and Europe